Solution complexation behaviour of 1,3,5-trioxycyclohexane based ligands and their evaluation as ionophores for Group IA/IIA metal cations
Abstract
A new series of cis,cis-cyclohexane-1,3,5-triol derivatives bearing one, two and three carbamoylalkyl substituents is reported. Ring interconversion promoted by intramolecular hydrogen bonding is observed for the mono- and di-alkylated derivatives 3 and 4 depending on 0) for the trioxa-equatorial ⇆ trioxa-axial equilibrium, modelling the conformational changes promoted by ion binding. Selectivity coefficients have been assessed electrochemically using fixed interference methods for the detection of biologically relevant IA/IIA metal