Issue 4, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 2

Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups

Xuhong Qian,*a   Tian-Bao Huang,b   Dong-zhi Wei,*c   Dong-Hui Zhu,c   Zhub  and  Wei Yaoc  

* Corresponding authors

a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China
E-mail: xhqian@ecust.edu.cn
Fax: 86(21)64251386

b Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, PO Box 544, Shanghai, China

c State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, PO Box 544, Shanghai, China

Abstract

The intercalation and photocleavage of DNA by N-[β-(N ′,N ′-dimethylamino)ethyl]dithiono-1,8-naphthalimide (2) were extremely effective compared to the use of the oxygen-containing counterpart (1). Their photocleavage action under 366 nm UV light is proposed to proceed by electron transfer from bases to the triplet state of the naphthalimides. The enhancement of the intercalation of DNA and the photocleavage of DNA were also observed for other compounds possessing a thiono or thio group compared with their oxygen-containing counterparts.

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Article information

DOI
https://doi.org/10.1039/A908787G
Article type
Paper
Submitted
04 Nov 1999
Accepted
14 Jan 2000
First published
14 Mar 2000

J. Chem. Soc., Perkin Trans. 2, 2000, 715-718

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Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups

X. Qian, T. Huang, D. Wei, D. Zhu, Zhu and W. Yao, J. Chem. Soc., Perkin Trans. 2, 2000, 715 DOI: 10.1039/A908787G

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