Synthesis of the novel amine (R*,R*,R*)-tris(α-methylbenzyl)amine. X-Ray crystal structures of racemic and enantiomerically pure forms

Paul Wyatt; Craig P. Butts; Vipulkumar Patel; Ben Voysey

doi:10.1039/B007710K

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Synthesis of the novel amine (R,R,R*)-tris(α-methylbenzyl)amine. X-Ray crystal structures of racemic and enantiomerically pure forms

Paul Wyatt,*^a Craig P. Butts,^b Vipulkumar Patel^c and Ben Voysey^a

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* Corresponding authors

^a School of Chemistry, Cantock’s Close, Bristol, UK

^b School of Chemistry, University of Exeter, Stocker Road, Exeter, UK

^c GlaxoWellcome, Gunnels Wood Road, Stevenage, Hertfordshire, UK

Abstract

Single diastereomers of tris(α-methylbenzyl)amine were efficiently synthesised in either racemic [(±)-1] or optically pure (1) form starting from α-methylbenzylamine. The X-ray crystal structures reveal virtually flat nitrogen centres.

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Supplementary files

Crystal structure data TXT (30K)

Article information

DOI: https://doi.org/10.1039/B007710K
Article type: Communication
Submitted: 22 Sep 2000
Accepted: 06 Nov 2000
First published: 22 Nov 2000

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J. Chem. Soc., Perkin Trans. 1, 2000, 4222-4223

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Synthesis of the novel amine (R,R,R*)-tris(α-methylbenzyl)amine. X-Ray crystal structures of racemic and enantiomerically pure forms

P. Wyatt, C. P. Butts, V. Patel and B. Voysey, J. Chem. Soc., Perkin Trans. 1, 2000, 4222 DOI: 10.1039/B007710K

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Journal of the Chemical Society, Perkin Transactions 1

Synthesis of the novel amine (R,R,R*)-tris(α-methylbenzyl)amine. X-Ray crystal structures of racemic and enantiomerically pure forms

Abstract

Supplementary files

Article information

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Synthesis of the novel amine (R,R,R*)-tris(α-methylbenzyl)amine. X-Ray crystal structures of racemic and enantiomerically pure forms

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