Highly stereoselective total synthesis of PM-Toxin B, a corn host-specific pathotoxin

Abstract

The highly stereoselective total synthesis of PM-toxin B, a corn host-specific toxin produced by the fungal pathogen Phyllosticta maydis, has been achieved by a convergent synthetic strategy which involves cross-aldol coupling of four key segments and the regioselective reductive cleavage of three α,β-epoxy ketone functionalities by an organoselenium reagent as key steps.