Enantiospecific total synthesis of both enantiomers of 2-thiocyanatoneopupukeanane from (R)-carvone

Abstract

Enantiospecific synthesis of both enantiomers of the marine sesquiterpene 2-thiocyanatoneopupukeanane starting from (R)-carvone, employing an intramolecular rhodium carbenoid C–H insertion reaction as the key step, is described.