Issue 17, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Chirally templated boronic acidMannich reaction in the synthesis of optically active α-amino acids

Gordon S. Currie,ab   Michael G. B. Drew,a   Laurence M. Harwood,*a   David J. Hughes,c   Richard W. A. Luked  and  Richard J. Vickersa  

* Corresponding authors

a Department of Chemistry, University of Reading, Whiteknights, Reading, UK

b Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK

c AstraZeneca Agrochemicals, Jealott′s Hill Research Station, Bracknell, Berkshire, UK

d AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK

Abstract

Adducts from diastereoselective Mannich-type reactions of aldehydes, 2-furylboronic acid and the chiral amine template (S )-5-phenylmorpholin-2-one, have been used in the synthesis of a series of enantiomerically pure D-α-amino acids.

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Article information

DOI
https://doi.org/10.1039/B003067H
Article type
Paper
Submitted
17 Apr 2000
Accepted
30 Jun 2000
First published
11 Aug 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 2982-2990

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Chirally templated boronic acid Mannich reaction in the synthesis of optically active α-amino acids

G. S. Currie, M. G. B. Drew, L. M. Harwood, D. J. Hughes, R. W. A. Luke and R. J. Vickers, J. Chem. Soc., Perkin Trans. 1, 2000, 2982 DOI: 10.1039/B003067H

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