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Issue 16, 2000
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Nickel(0)-catalysed asymmetric cross-coupling reactions of allylic compounds with Grignard reagents using optically active oxazolinylferrocenylphosphines as ligands

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Abstract

Optically active oxazolinylferrocenylphosphines work effectively as chiral P–N ligands in nickel(0)-catalysed cross-coupling reactions of allylic compounds with Grignard reagents, which are known to behave as “hard” nucleophiles, to give the expected coupling products in high yields and high enantioselectivities (30–100% chemical yield and 14–95% ee). These ligands are revealed to be more effective than optically active oxazolinylphenylphosphines which have only a central chirality.

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Article information


Submitted
30 Mar 2000
Accepted
15 Jun 2000
First published
19 Jul 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 2725-2729
Article type
Paper

Nickel(0)-catalysed asymmetric cross-coupling reactions of allylic compounds with Grignard reagents using optically active oxazolinylferrocenylphosphines as ligands

K. Chung, Y. Miyake and S. Uemura, J. Chem. Soc., Perkin Trans. 1, 2000, 2725
DOI: 10.1039/B002547J

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