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Issue 16, 2000
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Nickel(0)-catalysed asymmetric cross-coupling reactions of allylic compounds with Grignard reagents using optically active oxazolinylferrocenylphosphines as ligands

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Abstract

Optically active oxazolinylferrocenylphosphines work effectively as chiral P–N ligands in nickel(0)-catalysed cross-coupling reactions of allylic compounds with Grignard reagents, which are known to behave as “hard” nucleophiles, to give the expected coupling products in high yields and high enantioselectivities (30–100% chemical yield and 14–95% ee). These ligands are revealed to be more effective than optically active oxazolinylphenylphosphines which have only a central chirality.

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Publication details

The article was received on 30 Mar 2000, accepted on 15 Jun 2000 and first published on 19 Jul 2000


Article type: Paper
DOI: 10.1039/B002547J
Citation: J. Chem. Soc., Perkin Trans. 1, 2000,0, 2725-2729
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    Nickel(0)-catalysed asymmetric cross-coupling reactions of allylic compounds with Grignard reagents using optically active oxazolinylferrocenylphosphines as ligands

    K. Chung, Y. Miyake and S. Uemura, J. Chem. Soc., Perkin Trans. 1, 2000, 0, 2725
    DOI: 10.1039/B002547J

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