A simple, efficient and environment-friendly procedure is developed for the condensation of malononitrile with aromatic, heteroaromatic and aliphatic aldehydes in water. The ylidenemalononitriles 3 are synthesised in high yields (84–98%) and selectivities (87–98%) in distilled water at 65 °C for 1 h, avoiding the addition of any catalyst.
Clean synthesis in water: uncatalysed preparation of ylidenemalononitriles
F. Bigi, M. L. Conforti, R. Maggi, A. Piccinno and G. Sartori, Green Chem., 2000, 2, 101 DOI: 10.1039/B001246G
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