A new binuclear copper(II) complex [Cu2(H−4tapt)]·10H2O, where tapt is N,N′,N′′,N′′′-tetra(2-aminopropyl)-1,1,2,2-ethanetetraamide, has been synthesized and investigated in detail as a mimic of superoxide dismutase. Crystal structure analysis shows that each copper atom is situated in a slightly distorted square-pyramidal environment, with a water molecule at the apex. According to the result of pulse radiolysis, the complex has a high rate constant toward ˙O2−, kcat = 1.91 × 108 dm3 mol−1 s−1 (pH 7.4). Potentiometric titration shows that the mimic exhibits high stability at physiological pH value (7.4). EPR and ES-MS spectra reveal intermolecular interaction of two copper(II) nuclei.
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