Competitive binding of the anticancer drug titanocene dichloride to N,N′-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for TiIV uptake and release by transferrin

Maolin Guo; Peter J. Sadler

doi:10.1039/A908759A

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Competitive binding of the anticancer drugtitanocene dichloride to N,N′-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for Ti^IV uptake and release by transferrin

Maolin Guo^a and Peter J. Sadler*^a

Author affiliations

* Corresponding authors

^a The Department of Chemistry, University of Edinburgh, King’s Buildings, West Mains Road, Edinburgh, UK
E-mail: P.J.Sadler@ed.ac.uk

Abstract

¹H and ³¹P NMR studies show that in aqueous solution the anticancer agent titanocene dichloride (Cp₂TiCl₂) binds selectively to N,N′-ethylenebis(o-hydroxyphenylglycine) (H₄ehpg) at neutral pH, but preferentially to adenosine triphosphate (ATP) at pH* values below 5.1; intermolecular Ti^IV transfer from [Ti^IV(ehpg)(H₂O)] to ATP occurs at acidic pH values.

Download options Please wait...

Article information

DOI: https://doi.org/10.1039/A908759A
Article type: Communication
Submitted: 03 Nov 1999
Accepted: 19 Nov 1999
First published: 24 Dec 1999

Download Citation

J. Chem. Soc., Dalton Trans., 2000, 7-9

Permissions

Request permissions

Competitive binding of the anticancer drug titanocene dichloride to N,N′-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for Ti^IV uptake and release by transferrin

M. Guo and P. J. Sadler, J. Chem. Soc., Dalton Trans., 2000, 7 DOI: 10.1039/A908759A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Fetching data from CrossRef.
This may take some time to load.

Journal of the Chemical Society, Dalton Transactions