Crystal structure of the inclusion complex of cholic acid with 4-aminopyridine: a novel supramolecular architecture of cholic acid

Abstract

A lattice inclusion complex 1 of cholic acid (CA) with 4-aminopyridine (AP) has been prepared by a cocrystallization method, characterized by standard analytical techniques and structurally analyzed by single crystal X-ray diffraction in order to elucidate the characteristic supramolecular aggregation of host and guest molecules. X-ray crystallographic studies of this inclusion complex revealed that a channel type inclusion complex has been formed with novel hydrogen bonded helical network of cholic acid instead of the usually observed hydrogen bonded multibilayer arrangement.