Remote asymmetric induction by using the 1,3-migration reaction of (diene)iron tricarbonyl complexes

Abstract

Novel strategies for the stereoselective synthesis of molecules with remote stereogenic centers across double bonds have been developed via organoiron methodology allowing highly diastereoselective syntheses of 1,8- and 1,10-diol Fe(CO)₃ complexes using the stereospecific 1,3- and 1,5-migration of an Fe(CO)₃ group; this strategy could be used for stereoselective functionalization of remote terminal substituents on acyclic polyene compounds.