Replacement of the phosphodiester linkage in DNA with sulfamide and 3′-N-sulfamate groupsElectronic supplementary information (ESI) available: Experimental details for oligonucleotide synthesis and duplex denaturation experiments. See http://www.rsc.org/suppdata/cc/b0/b001586p/

Abstract

Replacing phosphodiester linkages in DNA with neutral 3′-N-sulfamate groups has little effect on the binding affinity for complementary DNA or RNA, whereas incorporation of sulfamide groups into DNA results in considerable destabilisation of isosequential duplexes.