13H-benzo[6-7]indolo[3,2-c]quinolines(B[6,7]IQ): optimization of their DNA triplex-specific stabilizationproperties

Philippe Schmitt; Chi Hung Nguyen; Jian-Sheng Sun; David S. Grierson; Emile Bisagni; Thérèse Garestier; Claude Hélène

doi:10.1039/B001318H

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13H-benzo[6-7]indolo[3,2-c]quinolines (B[6,7]IQ): optimization of their DNA triplex-specific stabilization propertiesElectronic supplementary information (ESI) available: experimental. See http://www.rsc.org/suppdata/cc/b0/b001318h/

Philippe Schmitt,^a Chi Hung Nguyen,^b Jian-Sheng Sun,*^a David S. Grierson,^b Emile Bisagni,^b Thérèse Garestier^a and Claude Hélène^a

Author affiliations

* Corresponding authors

^a Laboratoire de Biophysique, UMR 8646, CNRS-Muséum National d’Histoire Naturelle, INSERM U201, 43 rue Cuvier, Paris Cedex 05, France.
E-mail: sun@mnhn.fr

^b UMR 176 CNRS-Institut Curie, Section Recherche, Batiment 110, Centre Universitaire, Orsay, France

Abstract

The triple helix stabilization property of 13H-benzo[6-7]indolo[3,2-c]quinoline was significantly improved by changing the electron-donor acceptor properties of the substituent at position 10 or 11.

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Supplementary files

Experimental DOC (53K)

Article information

DOI: https://doi.org/10.1039/B001318H
Article type: Communication
Submitted: 17 Feb 2000
Accepted: 28 Mar 2000
First published: 18 Apr 2000

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Chem. Commun., 2000, 763-764

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13H-benzo[6-7]indolo[3,2-c]quinolines (B[6,7]IQ): optimization of their DNA triplex-specific stabilization properties

P. Schmitt, C. H. Nguyen, J. Sun, D. S. Grierson, E. Bisagni, T. Garestier and C. Hélène, Chem. Commun., 2000, 763 DOI: 10.1039/B001318H

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