Synthetic studies on calicheamicinγ1I—synthesis of (−)-calicheamicinone and models representing the four sugars andthe aromatic system

Derrick L. J. Clive; Yong Tao; Yunxin Bo; Yong-Zhou Hu; Natesan Selvakumar; Shaoyi Sun; Sylvain Daigneault; Yong-Jin Wu

doi:10.1039/B001204L

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Synthetic studies on calicheamicin γ₁^I—synthesis of (−)-calicheamicinone and models representing the four sugars and the aromatic system

Derrick L. J. Clive,*^a Yong Tao,^a Yunxin Bo,^a Yong-Zhou Hu,^a Natesan Selvakumar,^a Shaoyi Sun,^a Sylvain Daigneault^a and Yong-Jin Wu^a

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* Corresponding authors

^a Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada
E-mail: derrick.clive@ualberta.ca

Abstract

The synthesis of (−)-calicheamicinone (2), the carbohydrates 88, 101, 111, 119 and 120, and the hexasubstituted benzene 139, is described; these compounds formally represent the subunits of the antitumor antibiotic calicheamicin γ₁^I (1).

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Article information

DOI: https://doi.org/10.1039/B001204L
Article type: Feature Article
Submitted: 14 Feb 2000
Accepted: 02 May 2000
First published: 29 Jun 2000

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Chem. Commun., 2000, 1341-1350

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Synthetic studies on calicheamicin γ₁^I—synthesis of (−)-calicheamicinone and models representing the four sugars and the aromatic system

D. L. J. Clive, Y. Tao, Y. Bo, Y. Hu, N. Selvakumar, S. Sun, S. Daigneault and Y. Wu, Chem. Commun., 2000, 1341 DOI: 10.1039/B001204L

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