Asymmetric synthesis of alkyl 5-oxotetrahydrofuran-2-carboxylates by enantioselective hydrogenation of dialkyl 2-oxoglutarates over cinchona modified Pt/Al2O3catalysts
Abstract
The first direct asymmetric synthesis of chiral alkyl
5-oxo-tetrahydrofuran-2-carboxylates (up to 96% ee), which are important
building blocks in the synthesis of natural products by heterogeneous
cinchona-modified Pt-catalyzed hydrogenation of