An unprecedented one-step synthesis of unnatural α-amino acid and peptide derivatives, in both the racemic and optically pure forms, using azetidine-2,3-diones as building blocks has been developed by treatment with primary amines.
Unusual reaction of azetidine-2,3-diones with primary amines. Straightforward asymmetric synthesis of α-amino acid and peptide derivatives
B. Alcaide, P. Almendros and C. Aragoncillo, Chem. Commun., 2000, 757 DOI: 10.1039/A909688D
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