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Issue 11, 2000
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Photoelectrochemistry as a novel strategy for DNA hybridization detection

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Abstract

The special properties of ssDNA and dsDNA molecules in structure and electric behavior, may offer us some new ideas for the fabrication of genosensors and DNA-chips. In this work, the photoelectrochemical method was firstly employed to characterize the photoelectric behavior of a ssDNA probe electrode, which was prepared with the self-assembly technique, and its resulting dsDNA electrode. The obvious decrease in the photocurrent of the dsDNA modified electrode at open potential or a bias voltage indicated that photoelectrochemistry was another useful method for DNA hybridization detection. Using the special design of ssDNA probes, we attempt to discuss further the relationship between the properties of DNA molecules and their photoelectric behaviors. In addition, the electrochemical impedance method was employed to verify the occurrence of some modifications over the electrode interface before and after the hybridization event.

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Publication details

The article was received on 16 Aug 2000, accepted on 07 Sep 2000 and first published on 28 Sep 2000


Article type: Communication
DOI: 10.1039/B006699K
Analyst, 2000,125, 1908-1910

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    Photoelectrochemistry as a novel strategy for DNA hybridization detection

    L. Qingwen, L. Guoan, F. Jun, C. Dawen and O. Qi, Analyst, 2000, 125, 1908
    DOI: 10.1039/B006699K

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