Salbutamol plastic membrane electrodes based on individual and mixed ion-exchangers of salbutamolium phosphotungstate and phosphomolybdate

Abstract

Salbutamol (Sl), also known as albuterol, selective PVC membranes based on ion associates of salbutamolium phosphotungstate (Sl-PTA), salbutamolium phosphomolybdate (Sl-PMA) or a mixture of both (Sl-PTA/PMA) were prepared. The electrodes displayed a linear response over the concentration range 6.3 × 10⁻⁶–1.0 × 10⁻¹ mol dm⁻³ salbutamol sulfate (Sl₂SO₄). The working pH ranges of the above electrodes were 2.5–11.0, 3.0–11.0 and 2.5–10.5 and their isothermal temperature coefficients were 0.00095, 0.00105 and 0.00136 V °C⁻¹, respectively. The electrodes showed good selectivity to salbutamolium ion with respect to many inorganic cations, sugars and amino acids. The standard additions method was used to determine Sl₂SO₄ in pure solutions and pharmaceutical preparations with high accuracy and precision.