1,2-Dihydropyrrolo[1,2-c]pyrimidin-1-ones 2 have been synthesised from pyrrole. We have developed a versatile procedure for the introduction of substituents into the pyrrolopyrimidinones 2, at positions 5 or 7 as desired, and as required by our plans for the synthesis of the variolin type sea alkaloids.
M. Alvarez, D. Fernández and J. A. Joule, J. Chem. Soc., Perkin Trans. 1, 1999, 249 DOI: 10.1039/A809280J
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