Symmetric bis-substituted and asymmetric mono-substituted nitridotechnetium complexes with heterofunctionalized phosphinothiolate ligands

Abstract

The mixed bidentate ligand 2-(dicyclohexylphosphino)-ethanethiol (HL) reacts with labile nitrido-Tc precursors to afford a rare example of an asymmetric monosubstituted species [TcN(L)Cl(PPh₃)], 1, along with the symmetric bis-substituted complex [TcN(L)₂], 2. The latter compound, as assessed by TLC and HPLC chromatography, was found to possess the same molecular structure as the agent produced at the ‘non carrier added’ level utilizing the ^99mTc nuclear isomer.