Unsaturated, aryl and heteroaryl N-dialkyl-α-aminonitriles are easily oxidized at room temperature to their corresponding tertiary N-dialkylamides by using dimethyl sulfoxide and bases like ButOK or KOH. The reaction offers an efficient two-step conversion of aldehydes to N-dialkyamides.
D. Enders, A. S. Amaya and F. Pierre, New J. Chem., 1999, 23, 261 DOI: 10.1039/A809770D
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