Palladium-catalysed Heteroannulation with Acetylenic Carbinols: Synthesis of 3-Acylmethylisoindolin-1-ones
Abstract
Palladium-catalysed reactions of 2-iodobenzamides 1–6 with acetylenic carbinols 7–12 having a terminal acetylenic group and an adjacent carbinol functionality result in the formation of the 3-acylmethylisoindolin-1-ones 13–23 in one step.