Regioselective mono-addition of a range of Grignard reagents with the 5-esters of 3-methylisoxazole-4,5-diesters affords 5-keto derivatives instead of tertiary alcohols which is explained by the complexing ability of the isoxazole oxygen atom and by the electron withdrawing effect of the isoxazole ring.
K. J. Batchelor, W. Russell Bowman, R. V. Davies, M. H. Hockley and D. J. Wilkins, J. Chem. Res. (S), 1999, 428 DOI: 10.1039/A902259G
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