Fully substituted cyclooctatetraenes assembled by the [4 + 4] cross coupling of two different diene units: a shunting strategy of Wilke’s metallacyclopentadiene coupling mechanism†
Abstract
The first regio- and chemo-selective synthesis of fully substituted cyclooctatetraenes from two or three different alkynes was achieved using the cross-coupling between 1,4-dicuprabuta-1,3-dienes and 1,4-diiodobuta-1,3-dienes.