The total synthesis of (–)-α-kainic acid using titanium-mediated diene metallabicyclisation methodology
Abstract
Titanium-mediated diene metallabicyclisation–elimination–functionalisation has been utilised for the preparation of syn-3,4-disubstituted and syn,syn-2,3,4-trisubstituted pyrrolidines in high yield and excellent stereoselectivity; this methodology has been employed in a total synthesis of (–)-α-kainic acid starting from L-serine.