Hybrid QM/MM studies suggest that the conserved aspartate in protein kinases is not protonated during the phosphoryl transfer reaction, and thus does not act as a general base.
J. C. Hart, D. W. Sheppard, I. H. Hillier and N. A. Burton, Chem. Commun., 1999, 79 DOI: 10.1039/A808955H
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