Biologically remarkable 15-deoxy-TIC has been realised by the removal of the C(15) chiral centre in 15R-TIC, a stable ligand for a CNS-type prostacyclin receptor (IP2); this deoxy derivative exhibits ten-fold higher affinity and selectivity than 15R-TIC for the IP2 receptor in correlation with the anti-apoptotic activity for neuronal cells.
M. Suzuki, K. Kato, R. Noyori, Y. Watanabe, T. Satoh, K. Matsumura and Y. Watanabe, Chem. Commun., 1999, 307 DOI: 10.1039/A807613H
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