SCHEDULED MAINTENANCE
The total synthesis of physarorubinic acid, a polyenoyltetramic acid plasmoidal pigment from Physarum polycephalum, is described in a series of steps from (E
)-3-iodoacrylic acid 6 and employs aminolysis of the pentaene thioester 11 as a key synthetic step. Lacey–Dieckmann cyclisation and subsequent deprotection then affords physarorubinic acid 1 in high yield and purity.
D. J. Dixon, S. V. Ley and D. A. Longbottom, J. Chem. Soc., Perkin Trans. 1, 1999, 2231 DOI: 10.1039/A904921E
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