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Issue 14, 1999
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Exploring a chemical encoding strategy for combinatorial synthesis using Friedel–Crafts alkylation

Abstract

The use of scandium(III) triflate and ytterbium(III) triflate-catalysed Friedel–Crafts alkylation to insert a set of hydroxymethyl pyrrole amide tags (1b–i) on to polystyrene resins under mild conditions and the encoding of a split and mix peptide library is demonstrated.

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Article information


Chem. Commun., 1999, 1331-1332
Article type
Paper

Exploring a chemical encoding strategy for combinatorial synthesis using Friedel–Crafts alkylation

R. H. Scott, C. Barnes, U. Gerhard and S. Balasubramanian, Chem. Commun., 1999, 1331
DOI: 10.1039/A902489A

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