A novel and regioselective pyridine-ring formation by Lewis acid-induced cyclisation of 2-(N-allylbenzylamino)-3-[2,2-bis(ethoxycarbonyl)vinyl]pyrido[1,2-a]pyrimidin-4(4H)-one
Abstract
The Lewis acid-induced cyclisation of 2-(N++ -allylbenzylamino)-3-[2,2-bis(ethoxycarbonyl)vinyl]pyrido[1,2-++ a]pyrimidin-4(4H)-one 1a, which provides a novel and regioselective synthetic approach to the fused pyridine-ring, is described for the first time.