Electrochemical synthesis of euglobal-G1, -G2, -G3, -G4, -T1 and -IIc

Abstract

Six natural euglobals were synthesized by electrochemical methods. In a key step, cycloaddition between in situ generated quinomethanes and terpenes was performed on the surface of PTFE-fibre coated electrode to give natural products using 2,3-dichloro-5,6-dicyano-p-hydroquinone (DDQH₂) as a redox mediator. In this reaction system, biomimetic generation and cycloaddition of the unstable quinomethanes were efficiently completed by the selective oxidation of cresol derivatives.