A one-step synthesis of 1-substituted thieno[2,3-f]benzo[cd]indol-4-ones via benzyne-3-carboxylate

Abstract

4-Substituted bromobenzoic acids react with 3-thienylacetonitrile under aryne-forming conditions (LDA) to give the corresponding thieno[2,3-f]benzo[cd]indol-4-ones; this constitutes the first reported synthesis of this heretofore unknown tetracyclic heterocycle.