(R)-(–)-Elenic acid 1, an inhibitor of topoisomerase II isolated from the marine sponge Plakinastrella sp., has been synthesized starting from hexadecane-1,16-diol 2 and methyl (S
)-3-hydroxy-2-methylpropanoate 6.
S. Takanashi, M. Takagi, H. Takikawa and K. Mori, J. Chem. Soc., Perkin Trans. 1, 1998, 1603 DOI: 10.1039/A801122B
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