Stereoselective construction of the key intermediate for the synthesis of the tetrahydropyranyl antifungal agents (+)-restricticin and (+)-lanomycin
Abstract
Stereoselective construction of the key intermediate for the synthesis of naturally occurring antifungal agents, such as (+)-restricticin and (+)-lanomycin, has been achieved by employing a chelation-controlled aldol reaction of methyl α-methyltetronate with (R)-cyclohexylideneglyceraldehyde as a key step.