A novel synthesis of chiral cyclic hydroxamic acids (4, 6, 8 and 10) related to cyclodipeptides is described. The crucial reduction of the nitro group of the N-nitroacetyl derivatives of (S
)-α-amino acid esters is brought about by zinc–aq. ammonium chloride. The FeIII and CuII complexes of one such cyclic hydroxamic acid 10a have been prepared and their DNAse activity investigated.
P. Chittari, V. R. Jadhav, K. Nagappa Ganesh and S. Rajappa, J. Chem. Soc., Perkin Trans. 1, 1998, 1319 DOI: 10.1039/A707341K
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