Synthetic study of marine lobane diterpenes: efficient synthesis of (+)-fuscol
Abstract
As part of a synthetic study on marine natural products, the enantioselective synthesis of (+)-fuscol 4, a representative lobane diterpene, has been achieved in 10 steps and ca. 20% overall yield from (4R,5R)-1-acetoxy-4-isopropenyl-5-methyl-5-vinylcyclohex-1-ene 3b, which itself has been prepared as a building block directed toward the asymmetric synthesis of natural products, in more than 40% overall yield from (+)-nopinone 1.