Regio- and Stereo-selective Reaction of Chiral Alkoxy- and Aminomethyl-substituted α-Silylallyl Carbanions with Aldehydes
Abstract
The reactions of chiral alkoxy- and aminomethyl-substituted α-silylallyl carbanions with aldehydes gave 1-silyl-homoallylic alcohols with high γ-regioselection and E-stereoselection, as well as a diastereomeric excess of 8–69%, depending on the chiral substituents on silicon, the aldehydes and the base used.