Alumina in Methanesulfonic Acid (AMA) as a New Efficient Reagent for Direct Acylation of Phenol Derivatives and Fries Rearrangement. A Convenient Synthesis of o-Hydroxyarylketones
Abstract
Alumina in methanesulfonic acid is used to prepare o-hydroxyarylketones, by acylation of phenol and naphthol derivatives with carboxylic acids and Fries rearrangement of phenolic esters.