Issue 1, 1998

New Synthesis of Fused Pyrimidine Derivatives via ortho-(Isocyanomethyl)nitroaromatic Compounds

Abstract

An efficient synthesis of functionalized fused pyrimidine derivatives from the respective ortho-(isocyanomethyl)nitroarenes is described: hydrolysis of the isocyano group in the title isocyanides followed by catalytic reduction of the nitro group and subsequent cyclocondensation of the diamine formed with orthoesters leads to the final products.

Article information

Article type
Paper

J. Chem. Res. (S), 1998, 14-15

New Synthesis of Fused Pyrimidine Derivatives via ortho-(Isocyanomethyl)nitroaromatic Compounds

S. Ostrowski, J. Chem. Res. (S), 1998, 14 DOI: 10.1039/A703092D

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