A highly cytotoxic L-rhamnose analogue of the antitumour agent spicamycin
Abstract
Rhamnospicamycin 2, a rhamnose analogue (containing adenine, a carbohydrate, an amino acid and a fatty acid) of the naturally occurring combinatorial library spicamycin 1, is prepared from L-rhamnose and shown to be highly cytotoxic towards human myeloma cells (IC50 = 120 nM).