UV-induced strand break damage in single stranded bromodeoxyuridine-containing DNA oligonucleotides
Abstract
Aerobic UVB photolysis of single stranded bromodeoxyuridine (BrdU)-containing DNA oligonucleotides produces immediate and latent strand break products consistent with a specific BrdU base radical-mediated abstraction of the C1′ hydrogen atom from the 5′ neighbouring deoxyribose.