Issue 10, 1998

Stereoselective conversion of 2′,3′-dideoxydidehydro carbocyclic nucleosides into 2′-deoxy carbocyclic nucleosides

Abstract

Treatment of 2′,3′-dideoxydidehydro carbocyclic nucleosides 5–9 with N-bromoacetamide in AcOH gives bromoesters 10–14 with good stereocontrol: debromination and hydrolysis furnishes 2′-deoxy carbocyclic nucleosides, e.g. 22.

Article information

Article type
Paper

Chem. Commun., 1998, 1117-1118

Stereoselective conversion of 2′,3′-dideoxydidehydro carbocyclic nucleosides into 2′-deoxy carbocyclic nucleosides

J. V. Barkley, A. Dhanda, M. Nielsen, S. M. Roberts, L. J. S. Knutsen and D. R. Varley, Chem. Commun., 1998, 1117 DOI: 10.1039/A801759J

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