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Issue 4, 1998
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LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Abstract

A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson–Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.

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Article type: Paper
DOI: 10.1039/A708608C
Citation: Chem. Commun., 1998,0, 455-456
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    LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

    S. K. Singh, A. A. Koshkin, J. Wengel and P. Nielsen, Chem. Commun., 1998, 0, 455
    DOI: 10.1039/A708608C

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