Tandem Michael-aldol induced ring closure of dimethyl 2-phenylselenofumarate: a diastereoselective entry to novel 4-phenylseleno butano-4-lactone derivatives, versatile precursors of naturally occurring compounds

Abstract

Tandem Michael-aldol induced ring closure of dimethyl 2-phenylsenofumarate gives, with good yields and diastereoselectivities, highly substituted 4-phenylselenobutano-4-lactones, which can be further transformed into naturally occurring substances.