Influence of steric crowding on the electrochemical reduction of substituted tertiary pyridylcarboxamides in aqueous acidic medium

Abstract

In order to assess the influence of the steric crowding on the electrochemical reduction of pyridylcarboxamides, we have studied a series of tertiary aromatic or alicyclic pyridylcarboxamides. We have shown that increasing steric hindrance at the amide nitrogen led to the production of either tetrahydropyridine or aminomethylpyridine.