Efficient chemoenzymatic synthesis of (2S,3S
)-3-hydroxyleucine mediated by immobilised penicillin G acylase
†
Abstract
Immobilised penicillin G acylase (EC 3.5.1.11) has been used in the key step to obtain optically pure (2S,3S
)-(+)-hydroxyleucine (ee >99%).
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)-3-hydroxyleucine mediated by immobilised penicillin G acylase