Sodium hydroxide-promoted reaction of 1-substituted 2,3,3-trifluoroprop-1-enyl toluene-p-sulfonates with alcohols. First efficient and convenient access to α-fluoro-β,β-dialkoxy ketones

Abstract

2,3,3-Trifluoro-1-aryl- or -1-alkyl-prop-1-enyl toluene-p-sulfonates 1, readily available from 2,2,3,3-tetrafluoropropanol, react smoothly with alcohols in the presence of sodium hydroxide at ambient temperature for 1 h to afford the corresponding α-fluoro-β,β-dialkoxy ketones 2 in good to excellent yields.