Aryltricyclospirodienones; novel steroid mimics as inhibitors of aromatase
Abstract
The aryltricyclospirodienones 16a, 16b, 16c and 18 have been
designed as potential inhibitors of aromatase and are synthesised from
6-methoxytetralone;
† compounds 16a and 18 have proved
effective inhibitors with activities of the same order as
aminoglutethimide.
† compounds 16a and 18 have proved
effective inhibitors with activities of the same order as
aminoglutethimide.
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