A radio-iodinated abscisic acid photoaffinity probe

Abstract

The construction of a photoaffinity probe based on abscisic acid is described. A strategy based on C-4′-tethering of aromatic hydrazides led to abscisic acid 4′-(3″-azido-4″ -hydroxybenzoylhydrazide). This compound is of moderate biological activity in cereal aleurone assays and was readily iodinated with chloramine T and sodium iodide, conditions that were used for the preparation of the [¹²⁵I]-labelled compound in high radiochemical yield.